Journal article
Modulation of Dopamine Receptor Agonist-Induced Rotational Behavior in 6-OHDA-Lesioned Rats by a Peptidomimetic Analogue of Pro-Leu-Gly-NH2 (PLG)
Abstract
The present study was undertaken to determine if the previously reported in vitro interactions of the Pro-Leu-Gly-NH2 (PLG) peptidomimetic analogue 3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacet amide (PAOPA) with the dopaminergic system could be exhibited in an in vivo animal model using 6-hydroxydopamine (6-OHDA)-lesioned rats. In this model, PAOPA was found to potentiate the contralateral rotational behavior induced by …
Authors
Mishra RK; Marcotte ER; Chugh A; Barlas C; Whan D; Johnson RL
Journal
Peptides, Vol. 18, No. 8, pp. 1209–1215
Publisher
Elsevier
Publication Date
January 1997
DOI
10.1016/s0196-9781(97)00147-2
ISSN
0196-9781