Journal article
Mesolimbic and striatal dopamine receptor supersensitivity: Prophylactic and reversal effects of L-prolyl-L-leucyl-glycinamide (PLG)
Abstract
Functional supersensitivity of mesolimbic and striatal dopamine receptors has been suggested to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. Using the rodent model of chronic administration of the neuroleptic haloperidol, we investigated the possible desensitizing effects of a tripeptide structurally unrelated to dopamine agonists, L-prolyl-L-leucyl-glycinamide (PLG) on mesolimbic and striatal dopaminergic receptor …
Authors
Chiu P; Rajakumar G; Chiu S; Johnson RL; Mishra RK
Journal
Peptides, Vol. 6, No. 2, pp. 179–183
Publisher
Elsevier
Publication Date
March 1985
DOI
10.1016/0196-9781(85)90036-1
ISSN
0196-9781