Journal article
CNS putative L-prolyl-L-leucyl-glycinamide (PLG) receptors, brain and lymphocyte dopamine receptors
Abstract
1. In view of previously demonstrated modulatory effects of PLG on the sensitivity of central dopamine receptors, we developed a radioligand binding assay to identify specific binding sites of PLG in rat and normal human brain. 2. 3H-PLG binds specifically to rat striatum exhibiting high affinity (KD = 4.69 +/- 0.50 nM) saturability (Bmax = 9.20 +/- 0.30 fmoles/mg protein) and reversibility; the highest density of specific PLG binding sites …
Authors
Chiu S; Ferris JA; Johnson R; Mishra RK
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 6, No. 4-6, pp. 365–368
Publisher
Elsevier
Publication Date
January 1982
DOI
10.1016/s0278-5846(82)80108-5
ISSN
0278-5846