Journal article
Effect of Standard vs Dose-Escalated Radiation Therapy for Patients With Intermediate-Risk Prostate Cancer: The NRG Oncology RTOG 0126 Randomized Clinical Trial
Abstract
Importance: Optimizing radiation therapy techniques for localized prostate cancer can affect patient outcomes. Dose escalation improves biochemical control, but no prior trials were powered to detect overall survival (OS) differences.
Objective: To determine whether radiation dose escalation to 79.2 Gy compared with 70.2 Gy would improve OS and other outcomes in prostate cancer.
Authors
Michalski JM; Moughan J; Purdy J; Bosch W; Bruner DW; Bahary J-P; Lau H; Duclos M; Parliament M; Morton G
Journal
JAMA Oncology, Vol. 4, No. 6,
Publisher
American Medical Association (AMA)
Publication Date
June 14, 2018
DOI
10.1001/jamaoncol.2018.0039
ISSN
2374-2437
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overDose-Response Relationship, RadiationFollow-Up StudiesGastrointestinal DiseasesHumansKaplan-Meier EstimateMaleMale Urogenital DiseasesMiddle AgedNeoplasm GradingNeoplasm MetastasisProstate-Specific AntigenProstatic NeoplasmsRadiation InjuriesRadiotherapy DosageRadiotherapy, ConformalRadiotherapy, Intensity-ModulatedSalvage TherapyTreatment Outcome