Journal article
Evidence for an effector role of endothelin in closure of the ductus arteriosus at birth
Abstract
The ductus arteriosus is a special muscular shunt that in the fetus allows blood to bypass the unexpanded lungs. It closes rapidly after birth and this event is initiated by the physiologic rise in blood oxygen tension. Endothelin-1 has been proposed by us as a local mediator for oxygen after demonstrating that it is formed within the ductus and is a potent ductus constrictor. To confirm this possibility, we have now measured the release of …
Authors
Coceani F; Kelsey L; Seidlitz E
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 70, No. 7, pp. 1061–1064
Publisher
Canadian Science Publishing
Publication Date
July 1, 1992
DOI
10.1139/y92-146
ISSN
0008-4212