Genetic analysis indicates that transcription factors AP-2alpha and Pax6 cooperate in the normal patterning and morphogenesis of the lens.

PURPOSE: The similar lens phenotypes observed in mice with mutations in the genes encoding either Pax6 or AP-2alpha suggested that these transcription factors work together to regulate specific signaling cascades during lens development. In this study we examined the overlapping expression patterns of Pax6 and AP-2alpha in the developing mouse lens and further investigated their potential cooperative roles through the creation of double …