Journal article
Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress
Abstract
Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate by activating key transcription factors. One such master regulator, the redox sensitive transcription factor NF E2 Related Factor 2 (NRF2), controls the expression of cellular defense genes including those encoding intracellular redox-balancing proteins involved in glutathione (GSH) synthesis. Under basal conditions, Kelch-like ECH-associated protein 1 …
Authors
Habib E; Linher-Melville K; Lin H-X; Singh G
Journal
Redox Biology, Vol. 5, , pp. 33–42
Publisher
Elsevier
Publication Date
August 2015
DOI
10.1016/j.redox.2015.03.003
ISSN
2213-2317
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid Transport System y+Breast NeoplasmsCell NucleusFemaleGene Expression Regulation, NeoplasticGlutamic AcidGlutathioneHumansHydrogen PeroxideIntracellular Signaling Peptides and ProteinsKelch-Like ECH-Associated Protein 1MCF-7 CellsNF-E2-Related Factor 2Oxidative StressPromoter Regions, GeneticProtein SubunitsRNA InterferenceRNA, Small InterferingReactive Oxygen SpeciesUp-Regulation