Journal article
Hyperglycemia promotes insulin-independent ovarian tumor growth
Abstract
INTRODUCTION: Epithelial ovarian cancer (EOC) is notoriously difficult to diagnose in its earlier and more treatable stages, making it one of the deadliest cancers in women. Comorbid diabetes is associated with poor prognosis in EOC and pro-growth insulin signalling is often considered to be the driving factor. However, EOC cells are also highly glycolytic and insulin-independent glucose uptake is essential to their metabolism. Evidence of …
Authors
Kellenberger LD; Petrik J
Journal
Gynecologic Oncology, Vol. 149, No. 2, pp. 361–370
Publisher
Elsevier
Publication Date
May 2018
DOI
10.1016/j.ygyno.2018.02.003
ISSN
0090-8258
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlood GlucoseCarcinoma, Ovarian EpithelialCell Line, TumorCulture MediaDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Disease Models, AnimalFemaleGlucoseHyperglycemiaInsulinMiceMice, Inbred C57BLMice, KnockoutNeoplasm InvasivenessNeoplasms, Glandular and EpithelialOvarian Neoplasms