Long‐term caloric restriction increases apoptosis and decreases cell stress response, despite an elevation in antioxidant enzyme capacity in the skeletal muscle of the Cu/Zn‐SOD mutant G93A mouse, an animal model of ALS

Despite its life‐extending properties, long‐term caloric restriction (CR) hastens clinical onset and shortens life span in the G93A mouse, an animal model of ALS (Hamadeh et al , 2005; Hamadeh and Tarnopolsky, 2005). We previously reported that CR increased lipid peroxidation (MDA) in this model (Patel et al , 2007). We hypothesized that CR would increase apoptosis and decrease cell stress response, with an incomplete compensatory upregulation …