The effect of exercise on markers of oxidative stress in a mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease associated with oxidative stress. G93A mice are a transgenic strain that overexpress mutant CuZn superoxide dismutase (SOD1mut) and are a model for ALS. Endurance exercise increases antioxidant capacity in healthy skeletal muscle; however, it is unclear whether exercise is beneficial or deleterious in disorders with inherently high oxidative stress. We examined the effect of …