Sterile filtration of oncolytic viruses: An analysis of effects of membrane morphology on fouling and product recovery

Oncolytic viruses (OVs) are an emerging class of bio-therapeutics that have attracted significant interest due to their inherent specificity for targeting malignant tissues in cancer immunotherapy. One of the main challenges in many OVs manufacturing processes is the dead-end sterile filtration step that is highly desirable from a safety and regulatory perspective. The primary issue is the severe membrane fouling, as indicated by a dramatic and …