Acute toxicity of benzene inhalation to hemopoietic precursor cells

When BDF1 mice were submitted to inhalation of benzene vapors (4680 ppm) for 8 hr, a significant depletion in bone marrow colony forming cells (CFC) was observed in cultures in vitro assayed 1 day after drug inhalation; however, femoral CFC returned to steady state values by Day 7. The return of femoral CFC values was not due to an increase in bone marrow cellularity. Although spleen cellularity increased significantly by Days 4 and 7, the …