Journal article
Incomplete Inhibition of Thromboxane Biosynthesis by Acetylsalicylic Acid
Abstract
BACKGROUND: Incomplete inhibition of platelet thromboxane generation, as measured by elevated urinary 11-dehydro thromboxane B(2) concentrations, has been associated with an increased risk of cardiovascular events. We aimed to determine the external validity of this association in aspirin-treated patients enrolled in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial and to …
Authors
Eikelboom JW; Hankey GJ; Thom J; Bhatt DL; Steg PG; Montalescot G; Johnston SC; Steinhubl SR; Mak K-H; Easton JD
Journal
Circulation, Vol. 118, No. 17, pp. 1705–1712
Publisher
Wolters Kluwer
Publication Date
October 21, 2008
DOI
10.1161/circulationaha.108.768283
ISSN
0009-7322