Journal article
Do trials reduce uncertainty? Assessing impact through cumulative meta-analysis of neonatal RCTs
Abstract
Objective:To assess the impact of the latest randomized controlled trial (RCT) to each systematic review (SR) in Cochrane Neonatal Reviews.Study Design:We selected meta-analyses reporting the typical point estimate of the risk ratio for the primary outcome of the latest study (n=130), mortality (n=128) and the mean difference for the primary outcome (n=44). We employed cumulative meta-analysis to determine the typical estimate after each trial …
Authors
Hay SC; Kirpalani H; Viner C; Soll R; Dukhovny D; Mao W-Y; Profit J; DeMauro SB; Zupancic JAF
Journal
Journal of Perinatology, Vol. 37, No. 11, pp. 1215–1219
Publisher
Springer Nature
Publication Date
November 2017
DOI
10.1038/jp.2017.126
ISSN
0743-8346