Journal article
Amygdala responses to quetiapine XR and citalopram treatment in major depression: the role of 5‐HTTLPR‐S/Lg polymorphisms
Abstract
OBJECTIVES: Genotype and drug pharmacology may contribute to variations in brain response to antidepressants. We examined the impact of two antidepressants with differential actions on serotonin transporter and the 5-HHTLPR-S/Lg polymorphisms on amygdala responses in major depressive disorder (MDD).
METHODS: Caucasians with MDD were given either citalopram or quetiapine extended release for 8 weeks. Patients were genotyped for 5-HTTLPR. …
Authors
Ramasubbu R; Burgess A; Gaxiola-Valdez I; Cortese F; Clark D; Kemp A; Goodyear B; Macqueen G; Bech-Hansen NT; Foster J
Journal
Human Psychopharmacology Clinical and Experimental, Vol. 31, No. 2, pp. 144–155
Publisher
Wiley
Publication Date
March 2016
DOI
10.1002/hup.2521
ISSN
0885-6222
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAmygdalaCitalopramDelayed-Action PreparationsDepressive Disorder, MajorDouble-Blind MethodFemaleGenotyping TechniquesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPolymorphism, GeneticQuetiapine FumarateSerotonin Plasma Membrane Transport ProteinsTreatment OutcomeWhite PeopleYoung Adult