Journal article
A Pilot Study of Hypofractionated Stereotactic Radiation Therapy and Sunitinib in Previously Irradiated Patients With Recurrent High-Grade Glioma
Abstract
PURPOSE/OBJECTIVE(S): Angiogenic blockade with irradiation may enhance the therapeutic ratio of radiation therapy (RT) through vascular normalization. We sought to determine the safety and toxicity profile of continuous daily-dosed sunitinib when combined with hypofractionated stereotactic RT (fSRT) for recurrent high-grade gliomas (rHGG).
METHODS AND MATERIALS: Eligible patients had malignant high-grade glioma that recurred or progressed after …
Authors
Wuthrick EJ; Curran WJ; Camphausen K; Lin A; Glass J; Evans J; Andrews DW; Axelrod R; Shi W; Werner-Wasik M
Journal
International Journal of Radiation Oncology • Biology • Physics, Vol. 90, No. 2, pp. 369–375
Publisher
Elsevier
Publication Date
October 2014
DOI
10.1016/j.ijrobp.2014.05.034
ISSN
0360-3016
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AdultAgedAngiogenesis InhibitorsAntineoplastic AgentsBrain NeoplasmsCombined Modality TherapyDisease-Free SurvivalDose Fractionation, RadiationDrug Administration ScheduleFemaleGliomaHumansIndolesMaleMiddle AgedNeoplasm Recurrence, LocalPilot ProjectsPyrrolesRadiosurgeryRemission InductionRetreatmentSunitinib