Journal article
High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists
Abstract
HDL carries biologically active lipids such as sphingosine-1-phosphate (S1P) and stimulates a variety of cell signaling pathways in diverse cell types, which may contribute to its ability to protect against atherosclerosis. HDL and sphingosine-1-phosphate receptor agonists, FTY720 and SEW2871 triggered macrophage migration. HDL-, but not FTY720-stimulated migration was inhibited by an antibody against the HDL receptor, SR-BI, and an inhibitor …
Authors
Al-Jarallah A; Chen X; González L; Trigatti BL
Journal
PLOS ONE, Vol. 9, No. 9,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0106487
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell LineCell MovementCells, CulturedFingolimod HydrochlorideIntracellular Signaling Peptides and ProteinsLipoproteins, HDLMacrophagesMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutOxadiazolesPertussis ToxinPropylene GlycolsProto-Oncogene Proteins c-aktReceptors, LysosphingolipidScavenger Receptors, Class BSphingosineThiophenes