Disruption of blastocyst implantation by triclosan in mice: Impacts of repeated and acute doses and combination with bisphenol-A

Triclosan is an antimicrobial additive in many personal care and household products, and evidence indicates that it can be estrogenic. As estrogen elevations can disrupt blastocyst implantation, we examined the influence of triclosan on implantation in inseminated mice. Doses of 18 and 27 mg/animal/day (about 523 and 785 mg/kg/day) on gestational days (GD) 1-3 reduced the number of implantation sites on GD 6. Single doses on GD 2 or 3 also …