Journal article
Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits
Abstract
Diet greatly influences gene expression and physiology. In mammals, elucidating the effects and mechanisms of individual nutrients is challenging due to the complexity of both the animal and its diet. Here, we used an interspecies systems biology approach with Caenorhabditis elegans and two of its bacterial diets, Escherichia coli and Comamonas aquatica, to identify metabolites that affect the animal's gene expression and physiology. We …
Authors
Watson E; MacNeil LT; Ritter AD; Yilmaz LS; Rosebrock AP; Caudy AA; Walhout AJM
Journal
Cell, Vol. 156, No. 4, pp. 759–770
Publisher
Elsevier
Publication Date
February 2014
DOI
10.1016/j.cell.2014.01.047
ISSN
0092-8674