Clinical application of a semimechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy

Purpose: The objective of these analyses was to examine the effect of variations in the explanatory factors of neutropenic response, identified by semimechanistic-physiologic population pharmacokinetic/pharmacodynamic (PK/PD) modeling, on clinically important features of the absolute neutrophil count (ANC)-time profile (e.g, the nadir of the ANC [NANC], its timing [TNadir], and the timecourse of recovery [TRec]). Methods: Correlation analyses …