Expression of the large T antigens of SV40 and Polyomavirus sensitizes normal human diploid fibroblasts to UV and cisplatin

OX A damaging agents induce accumulation and increased activitv of poof which is thought to lead to increased IA repair, cell cycle arrest and apoptosis. Although these responses are protective against transformation, the net effect of p53 dependant responses on cell survival is not entirely clear as t host1 outcomes have opposing effects. Cell cycle arrest appears to be mediated by transcriptional activation of the cyclin dependant kinase …