Journal article
Lysine–poly(2-hydroxyethyl methacrylate) modified polyurethane surface with high lysine density and fibrinolytic activity
Abstract
We have developed a potentially fibrinolytic surface in which a bioinert polymer is used as a spacer to immobilize lysine such that the ε-amino group is free to capture plasminogen when in contact with blood. Adsorbed plasminogen can be activated to plasmin and potentially dissolve nascent clots formed on the surface. In previous work lysine was immobilized through a poly(ethylene glycol) (PEG) spacer; however, the graft density of PEG was …
Authors
Li D; Chen H; Wang S; Wu Z; Brash JL
Journal
Acta Biomaterialia, Vol. 7, No. 3, pp. 954–958
Publisher
Elsevier
Publication Date
March 2011
DOI
10.1016/j.actbio.2010.10.021
ISSN
1742-7061