Journal article
Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania
Abstract
OBJECTIVE: In the present study, we aimed to examine the effects of repeated D-amphetamine (AMPH) exposure, a well-accepted animal model of acute mania in bipolar disorder (BD), and histone deacetylase (HDAC) inhibitors on locomotor behavior and HDAC activity in the prefrontal cortex (PFC) and peripheral blood mononuclear cells (PBMCs) of rats. Moreover, we aimed to assess brain-derived neurotrophic factor (BDNF) protein and mRNA levels in …
Authors
Stertz L; Fries GR; de Aguiar BW; Pfaffenseller B; Valvassori SS; Gubert C; Ferreira CL; Moretti M; Ceresér KM; Kauer-Sant'Anna M
Journal
Brazilian Journal of Psychiatry, Vol. 36, No. 1, pp. 39–46
Publisher
EDITORA SCIENTIFIC
Publication Date
2014
DOI
10.1590/1516-4446-2013-1094
ISSN
1516-4446