Journal article
TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation
Abstract
The receptor-regulated Smad proteins are essential intracellular mediators of signal transduction by the transforming growth factor-β (TGF-β) superfamily of growth factors and are also important as regulators of gene transcription. Here we describe a new role for TGF-β-regulated Smad2 and Smad3 as components of a ubiquitin ligase complex. We show that in the presence of TGF-β signalling, Smad2 interacts through its proline-rich PPXY motif with …
Authors
Bonni S; Wang H-R; Causing CG; Kavsak P; Stroschein SL; Luo K; Wrana JL
Journal
Nature Cell Biology, Vol. 3, No. 6, pp. 587–595
Publisher
Springer Nature
Publication Date
June 2001
DOI
10.1038/35078562
ISSN
1465-7392