Journal article
Recombination between the factor VIII gene and the DXS52 locus gives the most probable genetic order as centromere‐FRA(X)‐DXS15‐DXS52‐F8C‐telomere
Abstract
The linkage relationship between the factor VIII gene (F8C) and the DXS52 locus was examined in 8 families. Two recombinations were identified in 35 informative meioses (Zmax = 5.67; theta = 0.05), one in a family with hemophilia A, the other in a family with the fra(X) syndrome. Based on the latter recombination, the most probable order of loci was determined to be centromere-fra(X)-DXS15-DXS52-F8C-telomere. When these data are added to those …
Authors
Mulligan LM; Grover HJ; Blanchette VS; Giles AR; Lillicrap DP; Phillips A; Holden JJA; White BN; Opitz JM; Reynolds JF
Journal
American Journal of Medical Genetics, Vol. 26, No. 3, pp. 751–760
Publisher
Wiley
Publication Date
March 1987
DOI
10.1002/ajmg.1320260334
ISSN
0148-7299