Journal article
Induction of Cetacean Cytochrome P4501A1 by β-Naphthoflavone Exposure of Skin Biopsy Slices
Abstract
Marine mammals can accumulate environmental contaminants in their blubber at concentrations harmful to laboratory animals. Induction of the cytochrome P450 1A1 (CYP1A1) enzyme is widely used as a biomarker of exposure and molecular effects in animal species, yet the validity of this biomarker has not been established in marine mammals. In vivo studies are generally precluded in these protected species, but skin biopsies (epidermis and dermis) …
Authors
Godard CAJ; Smolowitz RM; Wilson JY; Payne RS; Stegeman JJ
Journal
Toxicological Sciences, Vol. 80, No. 2, pp. 268–275
Publisher
Oxford University Press (OUP)
Publication Date
8 2004
DOI
10.1093/toxsci/kfh124
ISSN
1096-6080