Journal article
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
Abstract
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent …
Authors
Wain LV; Vaez A; Jansen R; Joehanes R; van der Most PJ; Erzurumluoglu AM; O’Reilly PF; Cabrera CP; Warren HR; Rose LM
Journal
Hypertension, Vol. 70, No. 3, pp. e4–e19
Publisher
Wolters Kluwer
Publication Date
September 2017
DOI
10.1161/hypertensionaha.117.09438
ISSN
0194-911X