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Scholarly Works

In vivo Effects of Low Molecular Weight Heparins...

Journal article

In vivo Effects of Low Molecular Weight Heparins on Experimental Thrombosis and Bleeding

Abstract

Recent studies with heparin fractions indicate that it is possible to dissociate the antithrombotic and hemorrhagic effects of heparin and so improve its therapeutic potential. Heparin inhibits blood coagulation by 3 independent mechanisms by augmenting the effect of antithrombin HI (the major effect), by augmenting the inhibitory effect of thrombin or heparin cofactor II, and by disrupting the activation of blood coagulation on the platelet …

Authors

Hirsh J

Journal

Pathophysiology of Haemostasis and Thrombosis, Vol. 16, No. 2, pp. 82–86

Publisher

S. Karger AG

Publication Date

1986

DOI

10.1159/000215277

ISSN

1424-8832

Associated Experts

Jack Hirsh

Professor Emeritus, Faculty of Health Sciences

Labels

Medical Subject Headings (MeSH)

Animals Anticoagulants Antithrombin III Blood Coagulation Factor X Factor Xa Hemorrhage Heparin Heparitin Sulfate Molecular Weight Structure-Activity Relationship Thrombosis

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