Teichoic Acids Concept

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• PhoR autokinase activity is controlled by an intermediate in wall teichoic acid metabolism that is sensed by the intracellular PAS domain during the PhoPR‐mediated phosphate limitation response of Bacillus subtilis  Journal Articles
• B. subtilis LytR-CpsA-Psr Enzymes Transfer Wall Teichoic Acids from Authentic Lipid-Linked Substrates to Mature Peptidoglycan In Vitro  Journal Articles
• CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi–Bi reaction mechanism with micromolar Km values  Journal Articles
• Cell wall assembly in Bacillus subtilis: how spirals and spaces challenge paradigms  Journal Articles
• Characterization of Wall Teichoic Acid Degradation by the Bacteriophage ϕ29 Appendage Protein GP12 Using Synthetic Substrate Analogs  Journal Articles
• Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance  Journal Articles
• Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase  Journal Articles
• Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis  Journal Articles
• Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics  Journal Articles
• Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites  Journal Articles
• Development and Characterization of a Xylose-Dependent System for Expression of Cloned Genes in Bacillus subtilis : Conditional Complementation of a Teichoic Acid Mutant  Journal Articles
• Duplication of Teichoic Acid Biosynthetic Genes in Staphylococcus aureus Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases  Journal Articles
• High-Throughput Screening for Inhibitors of Wall Teichoic Acid Biosynthesis in Staphylococcus aureus  Journal Articles
• Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams  Journal Articles
• Lesions in Teichoic Acid Biosynthesis in Staphylococcus aureus Lead to a Lethal Gain of Function in the Otherwise Dispensable Pathway  Journal Articles
• Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor  Journal Articles
• New chemical tools to probe cell wall biosynthesis in bacteria  Journal Articles
• New screens and targets in antibacterial drug discovery  Journal Articles
• Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis  Journal Articles
• Purified, Recombinant TagF Protein from Bacillus subtilis 168 Catalyzes the Polymerization of Glycerol Phosphate onto a Membrane Acceptor in Vitro  Journal Articles
• Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance  Journal Articles
• Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria  Journal Articles
• Structure and mechanism ofStaphylococcus aureusTarM, the wall teichoic acid α-glycosyltransferase  Journal Articles
• Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis  Journal Articles
• Studies of the Genetics, Function, and Kinetic Mechanism of TagE, the Wall Teichoic Acid Glycosyltransferase in Bacillus subtilis 168  Journal Articles
• Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics  Journal Articles
• Teichoic Acid Is an Essential Polymer in Bacillus subtilis That Is Functionally Distinct from Teichuronic Acid  Journal Articles
• The N -Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in Bacillus subtilis and Staphylococcus aureus  Journal Articles
• The Amino Terminus of Bacillus subtilis TagB Possesses Separable Localization and Functional Properties  Journal Articles
• The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses  Journal Articles
• The TagB Protein in Bacillus subtilis 168 Is an Intracellular Peripheral Membrane Protein That Can Incorporate Glycerol Phosphate onto a Membrane-bound Acceptor in Vitro  Journal Articles
• The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III  Journal Articles
• The Wall Teichoic Acid Polymerase TagF Is Non-processive in Vitro and Amenable to Study Using Steady State Kinetic Analysis  Journal Articles
• Use of CDP-Glycerol as an Alternate Acceptor for the Teichoic Acid Polymerase Reveals that Membrane Association Regulates Polymer Length  Journal Articles
• Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis  Journal Articles