Sarah Svenningsen - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Assistant Professor, Medicine, Faculty of Health Sciences
Associate Member, Electrical and Computer Engineering, Faculty of Engineering
Affiliate Scientist, Firestone Institute for Respiratory Health, The Research Institute of St. Joe’s Hamilton
Canada Research Chair (Tier 2) in Translational Pulmonary Imaging, McMaster University,
Associate Member, School of Biomedical Engineering, Faculty of Engineering, McMaster University

Research Areas

Biomedical engineering (RA)
Biophysics (RA)
Other medical and biomedical engineering, n.e.c. (RA)
Respiratory diseases (RA)

Scholarly Activity in McMaster Experts

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selected scholarly activity

conferences
- Characterizing Inhaled Corticosteroid Deposition in Patients With Severe Asthma Based on Eosinophilic Inflammation and Airway Morphology. American Journal of Respiratory and Critical Care Medicine. 2024
- Effect of Dupilumab on Pulmonary Vascular Volume in Patients With Moderate-to-Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2024
- Magnetic Resonance Imaging Ventilation Phenotypes of Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2024
- Persistence of Mucus Plugging in Severe Asthmatics Treated With Biologics. American Journal of Respiratory and Critical Care Medicine. 2024
- Sputum Mucus Rheology, Inflammatory Profile, and CT Mucus Scores in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2024
- St. George's Respiratory Questionnaire (SGRQ) Based Cluster Analysis of Post-acute COVID-19 Sequelae. American Journal of Respiratory and Critical Care Medicine. 2024
- Ventilation Defect Burden Quantified by Technegas SPECT and ¹²⁹Xe MRI Predicts Lung Cancer Resection Outcomes. American Journal of Respiratory and Critical Care Medicine. 2024
- Effectiveness and cost of a comprehensive severe asthma management strategy guided by airway inflammometry. European Respiratory Journal. 2023
- Multisite implementation of 129Xe-MRI assessment of COPD disease progression: XeCITE early results. European Respiratory Journal. 2023
- Non-T2 cytokines post Benralizumab associate with residual symptoms. European Respiratory Journal. 2023
- Cell-free Tumor DNA in Blood and Bronchoalveolar Lavage (BAL) as a Biomarker in Non-Small Cell Lung Cancer. American Journal of Respiratory and Critical Care Medicine. 2023
- Dupilumab Reduces Sputum Eosinophils, Mucus Plugging and Improves Ventilation in Patients With Moderate-to-Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2023
- Respiratory Post Acute COVID-19 Sequelae (PACS)-A Phenotype of Long COVID. American Journal of Respiratory and Critical Care Medicine. 2023
- The Feasibility and Efficacy of Heated Humidified Air Via Nasal Cannula for COPD Patients Post Exacerbation: An Open-label, Non-randomized Pilot Study. American Journal of Respiratory and Critical Care Medicine. 2023
- Unique MRI Phenotypes Help Explain Post-Acute COVID-19 Syndrome. American Journal of Respiratory and Critical Care Medicine. 2023
- VQ-SPECT/CT Following Recovery From Non-critical COVID-19: 6 Month Longitudinal Follow-up. American Journal of Respiratory and Critical Care Medicine. 2023
- Elevated CD27-IgD- B cells in Post-Acute COVID-19 Sequalae Patients with Rheumatological Symptoms. 10.01 - Respiratory infections and bronchiectasis. 205. 2023
- Phosphoinositide 3-kinase and airway infections in severe asthmatics. European Respiratory Journal. 2022
- Respiratory system resistance and reactance following recovery from non-critical COVID-19. European Respiratory Journal. 2022
- Post-Acute COVID-19 Sequalae (PACS) with New-onset Rheumatological Complications. Arthritis & Rheumatology. 1583-1585. 2022
- Abnormal ¹²⁹Xe Ventilation MRI and Inhaled Corticosteroid Deposition in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2022
- Airway Inflammatory Endotypes and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2022
- Circulating Autoantibodies in Post-Acute Sequelae of COVID-19. American Journal of Respiratory and Critical Care Medicine. 2022
- Free-Breathing ¹H MRI Specific Ventilation and Biomarkers of Type-2 Inflammation in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2022
- Hyperpolarized ¹²⁹Xe Magnetic Resonance Imaging for the Assessment of Bronchiolitis Obliterans Syndrome (BOS) and Other Late-Onset Non-Infectious Pulmonary Complications (LONIPCs) Following Hematopoietic Stem Cell Transplantation. American Journal of Respiratory and Critical Care Medicine. 2022
- Prevalence and Clinical Relevance of Ventilation Heterogeneity and Luminal Cellular Inflammation in Lung Cancer Patients Prior to Lung Resection: An Interim Analysis. American Journal of Respiratory and Critical Care Medicine. 2022
- Ventilation and Perfusion Abnormalities Following Recovery from Non-Critical COVID-19. C30. LIFE AND LUNGS AFTER COVID: FUNCTIONAL RECOVERY AND OUTCOMES FOLLOWING SARS-CoV2 INFECTION. a3920-a3920. 2022
- Association Between CT Mucus Plugging and Airway Wall Thickness in COPD and Asthma. American Journal of Respiratory and Critical Care Medicine. 2021
- Bronchial Thermoplasty Guided by Inhaled Hyperpolarized Gas Magnetic Resonance Imaging in Severe Asthma: A One-Year Pilot Randomized Trial. American Journal of Respiratory and Critical Care Medicine. 2021
- Inspiratory and Expiratory Respiratory System Resistance in Severe Asthma Pre- and Post-Bronchodilator. American Journal of Respiratory and Critical Care Medicine. 2021
- Airway Luminal Contributors to Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 2019
- Determining the Minimal Clinically Important Difference: MRI Ventilation Defect Percent in Asthmatics. American Journal of Respiratory and Critical Care Medicine. 2018
- Effect of Anti-Th2 Therapy on MRI Ventilation Heterogeneity in Prednisone-Dependent Asthma. American Journal of Respiratory and Critical Care Medicine. 2018
- Five-year MRI study of ventilation heterogeneity in asthma. Imaging. pa799. 2017
- Fourier-decomposition of free-breathing pulmonary proton MRI in asthma. Imaging. pa800. 2017
- Ventilation heterogeneity reversibility: asthma, COPD or ACOS?. Imaging. oa4646. 2017
- Inflammatory And Non-Inflammatory Contributions To Ventilation Heterogeneity In Severe Poorly-Controlled Asthmatics. American Journal of Respiratory and Critical Care Medicine. 2017
- What Do Mri Ventilation Defects Reveal About Asthma Control?. American Journal of Respiratory and Critical Care Medicine. 2016
- Automated pulmonary lobar ventilation measurements using volume-matched thoracic CT and MRI. Proceedings of SPIE - The International Society for Optical Engineering. 941717-941717-9. 2015
- Fourier-based linear systems description of free-breathing pulmonary magnetic resonance imaging. Proceedings of SPIE - The International Society for Optical Engineering. 94171a-94171a-7. 2015
- Ventilation Heterogeneity In Severe Asthma: Effects Of Prednisone And Salbutamol Before Bronchial Thermoplasty. American Journal of Respiratory and Critical Care Medicine. 2015
- Development and application of pulmonary structure-function registration methods: towards pulmonary image-guidance tools for improved airway targeted therapies and outcomes. Proceedings of SPIE - The International Society for Optical Engineering. 90380y-90380y-11. 2014
- Oscillatory Positive Expiratory Pressure (oPEP) Treatment in Chronic Obstructive Pulmonary Disease. Chest. 741A-741A. 2013
- Hyperpolarized 129Xe MRI Feasibility, Subject Safety And Tolerability: At The Doorstep Of Clinical Translation?. A65. LUNG IMAGING: PHYSIOLOGY AND TECHNOLOGY. a2031-a2031. 2012
- Hyperpolarized 3He And 129Xe Magnetic Resonance Imaging Of Asthma. D30. NOVEL APPROACHES TO ASSESSING LUNG PATHOPHYSIOLOGY. a5586-a5586. 2012
- 129Xe Gas-Transfer MRI RBC-to-Barrier Ratio in Post-Acute COVID19 Syndrome: Clinically-relevant?. ISMRM Annual Meeting.
- Comparison of ventilation defects quantified by Technegas V-SPECT and hyperpolarized 129Xe MRI. Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition..
- Diaphragm Excursion Measured by Free-breathing 1H MRI in Patients with Asthma: Repeatability and Bronchodilator Response. Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition..
- The effect of variable compressed sense (CS) undersampling patterns in hyperpolarized Xenon (129Xe) diffusion-weighted MRI. Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition..
journal articles
- Computational fluid dynamics model predictions of inhaled corticosteroid deposition in patients with severe asthma.. Thorax. 80:425-432. 2025
- Sputum Cellularity and MRI Ventilation Defects in Severe Asthma.. Chest. S0012-3692(25)00648-8. 2025
- Quantification of 129Xe MRI Ventilation-defect-percent Using Binary-threshold, Gaussian Linear-Binning and K-means Methods: Differences in Asthma and COPD.. Academic Radiology. S1076-6332(25)00381-2. 2025
- Clinical Remission by a Comprehensive Severe Asthma Management Strategy Guided by Airway Inflammometry and Bioimaging. American Journal of Respiratory and Critical Care Medicine. 211:a7060-a7060. 2025
- Effect of Dupilumab on the Temporospatial Characteristics of Mucus Plugs in Patients With Moderate-to-Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 211:a1053-a1053. 2025
- The Age-dependent Upper Limit of Normal for Hyperpolarized 129 Xe MRI Ventilation Defect Percent in Healthy Individuals Using a Multi-center Database. American Journal of Respiratory and Critical Care Medicine. 211:a7952-a7952. 2025
- Design and Implementation of a Multi-Center Trial of 129Xe Gas Exchange MRI and MRS to Evaluate Longitudinal Progression of COPD.. Journal of Magnetic Resonance Imaging. 2025
- The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study.. BMJ Open. 15:e100568. 2025
- Pulmonary 129Xe MRI: CNN Registration and Segmentation to Generate Ventilation Defect Percent with Multi-center Validation.. Academic Radiology. 32:1734-1742. 2025
- A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging.. Journal of Magnetic Resonance Imaging. 2025
- Seeing the Unseen: Pulmonary MRI in Children with Post-COVID-19 Condition.. Radiology. 314:e250127. 2025
- Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID.. COPD: Journal of Chronic Obstructive Pulmonary Disease. 21:2394129. 2024
- Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals. Allergology International. 73:351-361. 2024
- Phosphoinositide‐3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations. Clinical and Experimental Allergy. 54:428-431. 2024
- Sampling pattern discrepancy in the application of compressed sensing hyperpolarized xenon‐129 lung MRI. NMR in Biomedicine. 37:e5121. 2024
- A Novel Computed Tomography Score Reveals More about Air Trapping in Asthma. American Journal of Respiratory and Critical Care Medicine. 209:1175-1176. 2024
- CT Airway Mucus in Older People Without Chronic Respiratory Illness. Chest. 166:429-432. 2024
- 129Xe MRI Ventilation Textures and Longitudinal Quality-of-Life Improvements in Long-COVID. Academic Radiology. 31:3825-3836. 2024
- Review of Hyperpolarized Pulmonary Functional ¹²⁹Xe MR for Long‐COVID. Journal of Magnetic Resonance Imaging. 59:1120-1134. 2024
- Review of Hyperpolarized Pulmonary Functional ¹²⁹Xe MR for Long‐COVID. Journal of Magnetic Resonance Imaging. 59:spcone-spcone. 2024
- Effect of dupilumab on sputum eosinophils in patients with moderate‐to‐severe asthma. Acta Allergologica. 79:509-513. 2024
- Phase-Resolved Functional Lung (PREFUL) MRI to Quantify Ventilation: Feasibility and Physiological Relevance in Severe Asthma. Academic Radiology. 31:3416-3426. 2024
- Benralizumab Normalizes Sputum Eosinophilia in Severe Asthma Uncontrolled by Anti–IL-5 Antibodies: A Single-Blind, Placebo-controlled Clinical Trial. American Journal of Respiratory and Critical Care Medicine. 208:1330-1335. 2023
- Specific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal Breathing ¹H MRI. Radiology: Cardiothoracic Imaging. 5:e230054. 2023
- Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-Controlled Trial. American Journal of Respiratory and Critical Care Medicine. 208:995-997. 2023
- Chest CT Findings 1 Year after COVID-19: Another Piece of the Post-Pandemic Puzzle. Radiology. 308:e231502. 2023
- More Data about ¹²⁹Xe MRI Ventilation Defects in Long COVID-19. Radiology. 307:e230479. 2023
- Longitudinal follow-up of postacute COVID-19 syndrome: DL_CO, quality-of-life and MRI pulmonary gas-exchange abnormalities. Thorax. 78:418-421. 2023
- Postacute COVID-19 Syndrome: ¹²⁹Xe MRI Ventilation Defects and Respiratory Outcomes 1 Year Later. Radiology. 307:e222557. 2023
- A case series of dual biologics therapy for severe asthma. Journal of Allergy and Clinical Immunology: In Practice. 11:335-340.e2. 2023
- Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms. European Respiratory Journal. 61:2200970-2200970. 2023
- Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarized 129Xe MRI. Frontiers in Physiology. 14:1133334. 2023
- Persistent ¹²⁹Xe MRI Pulmonary and CT Vascular Abnormalities in Symptomatic Individuals with Post-acute COVID-19 Syndrome. Radiology. 305:466-476. 2022
- Luminal mucus plugs are spatially associated with airway wall thickening in severe COPD and asthma: A single-centered, retrospective, observational study. Respiratory Medicine. 202:106982-106982. 2022
- Ventilation and perfusion abnormalities following recovery from noncritical COVID-19. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 6:304-313. 2022
- Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose. Chest. 162:520-533. 2022
- Imaging in Asthma-Chronic Obstructive Pulmonary Disease Overlap. Immunology and Allergy Clinics of North America. 42:601-614. 2022
- ¹²⁹Xe MRI ventilation defects in ever-hospitalised and never-hospitalised people with post-acute COVID-19 syndrome. BMJ Open Respiratory Research. 9:e001235-e001235. 2022
- Persistent Airway Plugs: A Call for Clinical Recognition and Novel Therapies. American Journal of Respiratory and Critical Care Medicine. 205:977-978. 2022
- Protocols for multi‐site trials using hyperpolarized ¹²⁹Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the ¹²⁹Xe MRI clinical trials consortium. Magnetic Resonance in Medicine. 86:2966-2986. 2021
- Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections. Viruses. 13:2239-2239. 2021
- Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: a 1-year pilot randomised trial. ERJ Open Research. 7:00268-2021. 2021
- There is more to severe asthma associated with obesity than inflammation. Respirology. 26:288-289. 2021
- Eosinophilia and Response to Bronchial Thermoplasty. American Journal of Respiratory and Critical Care Medicine. 203:148-148. 2021
- Lessons of the month: A breathless severe asthmatic in the genomic era: Occam's razor or Hickam's dictum?. Clinical Medicine. 20:e264-e266. 2020
- Effects of Anti-T2 Biologic Treatment on Lung Ventilation Evaluated by MRI in Adults With Prednisone-Dependent Asthma. Chest. 158:1350-1360. 2020
- Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility. Academic Radiology. 28:817-826. 2020
- Is Computed Tomography Airway Count Related to Asthma Severity and Airway Structure and Function?. American Journal of Respiratory and Critical Care Medicine. 201:923-933. 2020
- Nonidentical Twins With Asthma. Chest. 156:e111-e116. 2019
- Normalisation of MRI ventilation heterogeneity in severe asthma by dupilumab. Thorax. 74:1087-1088. 2019
- Hyperpolarized Helium 3 MRI in Mild-to-Moderate Asthma: Prediction of Postbronchodilator Reversibility. Radiology. 293:212-220. 2019
- Response. Chest. 156:808-809. 2019
- Optimizing sputum cell counts prior to bronchial thermoplasty: A preliminary report. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 3:143-147. 2019
- CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma. Chest. 155:1178-1189. 2019
- Clinical biomarkers and noninvasive assessment of severe asthma. ERS Monograph. 2019:93-112. 2019
- Eosinophil-derived IL-13 promotes emphysema. European Respiratory Journal. 53:1801291-1801291. 2019
- Sputum Antineutrophil Cytoplasmic Antibodies in Serum Antineutrophil Cytoplasmic Antibody–Negative Eosinophilic Granulomatosis with Polyangiitis. American Journal of Respiratory and Critical Care Medicine. 199:158-170. 2019
- Development of a pulmonary imaging biomarker pipeline for phenotyping of chronic lung disease. Journal of Medical Imaging. 5:1-1. 2018
- What is the minimal clinically important difference for helium-3 magnetic resonance imaging ventilation defects?. European Respiratory Journal. 51:1800324-1800324. 2018
- Free-breathing Pulmonary MR Imaging to Quantify Regional Ventilation. Radiology. 287:693-704. 2018
- Sputum Eosinophilia and Magnetic Resonance Imaging Ventilation Heterogeneity in Severe Asthma. American Journal of Respiratory and Critical Care Medicine. 197:876-884. 2018
- This is what asthma looks like: Review of new and emerging functional imaging methods and results. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 2:27-40. 2018
- Free-breathing Functional Pulmonary MRI. Academic Radiology. 24:1268-1276. 2017
- MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-to-moderate COPD: longitudinal TINCan study. Thorax. 72:475-477. 2017
- Thoracic CT‐MRI coregistration for regional pulmonary structure–function measurements of obstructive lung disease. Medical Physics. 44:1718-1733. 2017
- Ultrashort echo time MRI biomarkers of asthma. Journal of Magnetic Resonance Imaging. 45:1204-1215. 2017
- Asthma Endotypes and an Overview of Targeted Therapy for Asthma. Frontiers in Medicine. 4:158. 2017
- Glucocortiosteroid subsensitivity and asthma severity. Current Opinion in Pulmonary Medicine. 23:78-88. 2017
- Noncystic Fibrosis Bronchiectasis. Academic Radiology. 24:4-12. 2017
- Is ventilation heterogeneity related to asthma control?. European Respiratory Journal. 48:370-379. 2016
- Anatomical pulmonary magnetic resonance imaging segmentation for regional structure‐function measurements of asthma. Medical Physics. 43:2911-2926. 2016
- Hyperpolarized³He magnetic resonance imaging ventilation defects in asthma: relationship to airway mechanics. Physiological Reports. 4:e12761-e12761. 2016
- Ventilation Heterogeneity in Never-smokers and COPD:. Academic Radiology. 23:398-405. 2016
- Second-order Texture Measurements of 3He Ventilation MRI:. Academic Radiology. 23:176-185. 2016
- Oscillatory Positive Expiratory Pressure in Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease. 13:66-74. 2016
- Globally optimal co-segmentation of three-dimensional pulmonary 1H and hyperpolarized 3He MRI with spatial consistence prior. Medical Image Analysis. 23:43-55. 2015
- Differences in hyperpolarized ³He ventilation imaging after 4 years in adults with cystic fibrosis. Journal of Magnetic Resonance Imaging. 41:1701-1707. 2015
- Ultra-short echo-time pulmonary MRI: Evaluation and reproducibility in COPD subjects with and without bronchiectasis. Journal of Magnetic Resonance Imaging. 41:1465-1474. 2015
- Free-breathing Pulmonary 1H and Hyperpolarized 3He MRI. Academic Radiology. 22:320-329. 2015
- Pulmonary Functional Magnetic Resonance Imaging. Academic Radiology. 21:1402-1410. 2014
- Pulmonary ventilation defects in older never-smokers. Journal of applied physiology. 117:297-306. 2014
- Hyperpolarized ³ He and ¹²⁹ Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers. Physiological Reports. 2:e12068-e12068. 2014
- What are ventilation defects in asthma?. Thorax. 69:63-71. 2014
- Hyperpolarized ³He and ¹²⁹Xe MRI: Differences in asthma before bronchodilation. Journal of Magnetic Resonance Imaging. 38:1521-1530. 2013
- On the role of abnormal DL_COin ex-smokers without airflow limitation: symptoms, exercise capacity and hyperpolarised helium-3 MRI. Thorax. 68:752-759. 2013
- Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. Journal of applied physiology. 114:707-715. 2013
- Hyperpolarized³He and¹²⁹Xe MR Imaging in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease. Radiology. 265:600-610. 2012
- Hyperpolarized 129Xe Magnetic Resonance Imaging. Academic Radiology. 19:941-951. 2012
- Hyperpolarized 3He Magnetic Resonance Functional Imaging Semiautomated Segmentation. Academic Radiology. 19:141-152. 2012
- Quantitative Evaluation of Hyperpolarized Helium-3 Magnetic Resonance Imaging of Lung Function Variability in Cystic Fibrosis. Academic Radiology. 18:1006-1013. 2011
- Ventilation defect burden predicts lung cancer resection outcomes. ERJ Open Research. 01317-02024.
preprints
- Lasting changes to circulating leukocytes in people with mild SARS-CoV-2 infections 2021