Serological Immunoreactivity against Colon Cancer Proteome Varies upon Disease Progression Academic Article uri icon

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abstract

  • Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.

authors

  • De Monte, Lucia
  • Sanvito, Francesca
  • Olivieri, Stefano
  • Viganò, Fiammetta
  • Doglioni, Claudio
  • Frasson, Matteo
  • Braga, Manoela
  • Bachi, Angela
  • Dellabona, Paolo
  • Protti, Maria Pia
  • Alessio, Massimo

publication date

  • February 2008