Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers

This multicentre, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of using Emla (lignocaine/prilocaine) anaesthetic cream to achieve pain control during sharp debridement of chronic leg ulcers of arterial, venous or arteriovenous aetiology. A total of 101 patients (51 Emla, 50 placebo), aged 29–99 years, who had experienced pain associated with previous debridement were included. Patients with an amide anaesthetic allergy, anaesthetic diabetic ulcers, or ulcers >50cm2 were excluded. Debridement was initiated approximately 30 minutes after the application of a thick layer of Emla or placebo cream to an ulcer occluded with a plastic wrap. The patient and investigator assessed the pain associated with debridement on a 100mm visual analogue scale (VAS).The median patient VAS scores were 18mm and 53.5mm in the Emla and placebo groups, respectively (p<0.0001). The corresponding investigator values in the two groups were 20mm and 49.5mm, respectively (p=0.004). Local reactions were mainly transient and mild, and were observed in roughly the same percentage of placebo and Emla-treated patients. After a 30-minute application Emla cream significantly reduced the pain of debridement compared with the placebo.

Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers Journal Articles