Journal article
Association of BRM promoter polymorphisms and esophageal adenocarcinoma outcome
Abstract
PURPOSE: Brahma (BRM) is a critical catalytic subunit of the SWI/SNF chromatin remodeling complex; expression of BRM is commonly lost in various cancer types. BRM promoter polymorphisms (BRM-741; BRM-1321) are associated with loss of BRM expression, and with cancer risk/survival. We evaluated these two polymorphisms in the overall survival (OS) of esophageal adenocarcinoma (EAC) patients.
RESULTS: Of 270 patients, 37% were stage IV. Minor …
Authors
Korpanty GJ; Eng L; Qiu X; Faluyi OO; Renouf DJ; Cheng D; Patel D; Chen Z; Tse BC; Knox JJ
Journal
Oncotarget, Vol. 5, No. 0, pp. 28093–28100
Publisher
Impact Journals
Publication Date
April 25, 2017
DOI
10.18632/oncotarget.15890
ISSN
1949-2553
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenocarcinomaAdultAgedAged, 80 and overAllelesCombined Modality TherapyEsophageal NeoplasmsFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedNeoplasm StagingPolymorphism, GeneticPrognosisPromoter Regions, GeneticSurvival AnalysisTranscription Factors