Journal article
Mapping of dihydropyridine binding residues in a less sensitive invertebrate L-type calcium channel (LCav1)
Abstract
Invertebrate L-type calcium channel, LCa(v) 1, isolated from the pond snail Lymnaea stagnalis is nearly indistinguishable from mammalian Ca(v) 1.2 (α1C) calcium channel in biophysical characteristics observed in vitro. These L-type channels are likely constrained within a narrow range of biophysical parameters to perform similar functions in the snail and mammalian cardiovascular systems. What distinguishes snail and mammalian L-type channels …
Authors
Senatore A; Boone A; Lam S; Dawson TF; Zhorov B; Spafford JD
Journal
Channels, Vol. 5, No. 2, pp. 173–187
Publisher
Taylor & Francis
Publication Date
March 30, 2011
DOI
10.4161/chan.5.2.15141
ISSN
1933-6950
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAmino Acid SequenceAnimalsBiophysicsCalcium Channel BlockersCalcium Channels, L-TypeDihydropyridinesDose-Response Relationship, DrugHumansIsradipineKineticsLymnaeaModels, MolecularMolecular ConformationMolecular Sequence Data