Conference
223 Placental Transfer of the Protease Inhibitor Nelfinavir in the Dual in Vitro Placenta Perfusion Model
Abstract
Intro: The protease inhibitor nelfinavir is a common drug for treatment of HIV in pregnancy. Pairs of serum samples of maternal vein - and umbilical cord blood show very low levels of nelfinavir in umbilical cord blood. These results could be caused by an backward efflux of Nelfinavir into the maternal circulation by p-glycoprotein, which is highly expressed in the placenta. Nelfinavir is a known substrate of p-glycoprotein.Aim: Measurement of …
Authors
Linnemann K; Mehltretter D; May K; Siebert N; Kurowski M; Kroemer HK; Siegmund W; Fusch C
Volume
58
Pagination
pp. 392-392
Publisher
Springer Nature
Publication Date
August 2005
DOI
10.1203/00006450-200508000-00252
Conference proceedings
Pediatric Research
Issue
2
ISSN
0031-3998