Endoplasmic reticulum stress and lipid dysregulation Journal Articles

abstract

• Cellular cholesterol homeostasis is a fundamental and highly regulated process. Transcription factors known as sterol regulatory element binding proteins (SREBPs) coordinate the expression of many genes involved in the biosynthesis and uptake of cholesterol. Dysregulation of SREBP activation and cellular lipid accumulation has been associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). This review will provide an overview of ER stress and the UPR as well as cholesterol homeostasis and SREBP regulation, with an emphasis on their interaction and biological relevance.

authors

• Colgan, Stephen M
• Al-Hashimi, Ali A
• Austin, Richard C

status

• published 

publication date

• February 2011

has subject area

• 0601 Biochemistry and Cell Biology (FoR)
• Animals (MeSH)
• Cholesterol (MeSH)
• Endoplasmic Reticulum (MeSH)
• Feedback, Physiological (MeSH)
• Humans (MeSH)
• Immunology (Science Metrix)
• Lipid Metabolism (MeSH)
• Lipid Metabolism Disorders (MeSH)
• Sterol Regulatory Element Binding Protein 1 (MeSH)
• Sterol Regulatory Element Binding Protein 2 (MeSH)
• Transcriptional Activation (MeSH)
• Unfolded Protein Response (MeSH)

published in

• Expert Reviews in Molecular Medicine  Journal

keywords

• Animals
• Cholesterol
• Endoplasmic Reticulum
• Feedback, Physiological
• Humans
• Lipid Metabolism
• Lipid Metabolism Disorders
• Sterol Regulatory Element Binding Protein 1
• Sterol Regulatory Element Binding Protein 2
• Transcriptional Activation
• Unfolded Protein Response

Digital Object Identifier (DOI)

• 10.1017/s1462399410001742

PubMed ID

• 21288373

start page

• e4

volume

• 13