Journal article
Effects of Ramipril and Vitamin E on Atherosclerosis
Abstract
BACKGROUND: Activation of the renin-angiotensin-aldosterone system and oxidative modification of LDL cholesterol play important roles in atherosclerosis. The Study to Evaluate Carotid Ultrasound changes in patients treated with Ramipril and vitamin E (SECURE), a substudy of the Heart Outcomes Prevention Evaluation (HOPE) trial, was a prospective, double-blind, 3x2 factorial design trial that evaluated the effects of long-term treatment with the …
Authors
Lonn EM; Yusuf S; Dzavik V; Doris CI; Yi Q; Smith S; Moore-Cox A; Bosch J; Riley WA; Teo KK
Journal
Circulation, Vol. 103, No. 7, pp. 919–925
Publisher
Wolters Kluwer
Publication Date
February 20, 2001
DOI
10.1161/01.cir.103.7.919
ISSN
0009-7322
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAnalysis of VarianceAngiotensin-Converting Enzyme InhibitorsArteriosclerosisBlood PressureCarotid Artery DiseasesCreatinineDisease ProgressionDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient CompliancePotassiumProspective StudiesRamiprilRisk FactorsTreatment OutcomeUltrasonographyVitamin E