Journal article
Inhibition of VIP-stimulated intestinal secretion and cyclic AMP production by somatostatin in the rat
Abstract
The effect of somatostatin on colonic secretion induced by 10(-8) M vasoactive intestinal peptide (VIP), 10(-2) M theophylline, and 2 X 10(-3) M dibutyryl cyclic AMP was studied in muscle-stripped everted open rat colon sacs. The secretory response to VIP, measured as the decrease in net absorptive flow rate (microliters 30 min-1 mg-1 of dry weight), was maximal and equalled the responses to theophylline or dibutyryl cyclic AMP. Somatostatin …
Authors
Carter RF; Bitar KN; Zfass AM; Makhlouf GM
Journal
Gastroenterology, Vol. 74, No. 4, pp. 726–730
Publisher
Elsevier
Publication Date
April 1978
DOI
10.1016/0016-5085(78)90252-4
ISSN
0016-5085