Journal article
Human embryonic zeta-globin chain expression in deletional alpha- thalassemias
Abstract
zeta-Globin chain expression in carriers of a number of deletional alpha-thalassemias is investigated by radioimmunoassay. In a few cases, zeta-globin mRNAs are also studied. zeta-Globin chains are detected in (--SEA/), (--MED/), and (--SPAN/) deletions, but not in six other deletional mutations. These results suggest that the DNA element capable of suppressing zeta-globin expression in adult erythroid cells is present within the (--SPAN/) …
Authors
Tang W; Luo H; Albitar M; Patterson M; Eng B; Waye J; Liebhaber S; Higgs D; Chui D
Journal
Blood, Vol. 80, No. 2, pp. 517–522
Publisher
American Society of Hematology
Publication Date
July 15, 1992
DOI
10.1182/blood.v80.2.517.bloodjournal802517
ISSN
0006-4971