Journal article
Allelic Stability of VNTR Locus 3’αHVR: Linkage Disequilibrium with the Common α-Thalassaemia-1 Deletion of South-East Asia (--SEA/)
Abstract
Variable number of tandem repeats (VNTR) loci are among the most polymorphic sequences described to date. VNTR allelic variability is a function of the high rates of de novo mutation due to intra- and inter-allelic recombination. We have assessed the allelic stability of VNTRs during recent human evolution, focusing on the relationship between an alpha-thalassaemia-1 deletion that is common among South-East Asian populations (--SEA/) and a VNTR …
Authors
Waye JS; Eng B
Journal
Human Heredity, Vol. 44, No. 2, pp. 61–67
Publisher
Karger Publishers
Publication Date
1994
DOI
10.1159/000154192
ISSN
0001-5652