Journal article
Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial
Abstract
BACKGROUND: Previous animal and clinical studies showed that nitrous oxide may produce long-term analgesia. The aim of this study was to evaluate the effect of nitrous oxide in preventing chronic postsurgical pain. We also explored whether methylenetetrahydrofolate reductase gene polymorphisms (1298A>C, 667C>T) would enhance nitrous oxide analgesia.
METHODS: We conducted a telephone interview at 12 months after surgery on 2924 (41.1%) patients …
Authors
Chan MTV; Peyton PJ; Myles PS; Leslie K; Buckley N; Kasza J; Paech MJ; Beattie WS; Sessler DI; Forbes A
Journal
British Journal of Anaesthesia, Vol. 117, No. 6, pp. 801–811
Publisher
Elsevier
Publication Date
December 2016
DOI
10.1093/bja/aew338
ISSN
0007-0912