Journal article
Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent
Abstract
To study the effect of hydroxychloroquine (HCQ) on glucose and insulin homeostasis, healthy rats were dosed with 160 mg x kg (-1) x day(-1) of HCQ orally, and streptozocin-induced diabetic rats received 80, 120, and 160 mg x kg(-1) x day(-1) of HCQ, while controls received normal saline. Ten days after treatment with HCQ, healthy animals were challenged intravenously with insulin or glucose, while diabetic rats were given only an i.v. injection …
Authors
Emami J; Gerstein HC; Pasutto FM; Jamali F
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 77, No. 2, pp. 118–123
Publisher
Canadian Science Publishing
Publication Date
February 1, 1999
DOI
10.1139/y98-146
ISSN
0008-4212