Transplantation of Fetal CNS Tissue Into the Peripheral Nervous System: A Model to Study Aberrant Changes in the Neuronal Cytoskeleton

Defined regions (septum, substantia nigra) of the embryonic central nervous system (CNS) were transplanted into the sciatic nerves of young adult rats. Immunocytochemical techniques were used to examine the expression of neurotransmitter related enzymes and neuronal cytoskeletal proteins in the grafts. The origin of the septal grafts was confirmed by immunoreactivity in neurons to choline acetyltransferase and the beta-nerve growth factor …