Journal article
How to Use an Article About Genetic Association: A: Background Concepts
Abstract
This is the first in a series of 3 articles serving as an introduction to clinicians wishing to read and critically appraise genetic association studies. We summarize the key concepts in genetics that clinicians must understand to review these studies, including the structure of DNA, transcription and translation, patterns of inheritance, Hardy-Weinberg equilibrium, and linkage disequilibrium. We review the types of DNA variation, including …
Authors
Attia J; Ioannidis JPA; Thakkinstian A; McEvoy M; Scott RJ; Minelli C; Thompson J; Infante-Rivard C; Guyatt G
Journal
JAMA, Vol. 301, No. 1, pp. 74–81
Publisher
American Medical Association (AMA)
Publication Date
January 7, 2009
DOI
10.1001/jama.2008.901
ISSN
0098-7484