Effects of Smoking on Cure ofHelicobacter pyloriInfection and Duodenal Uulcer Recurrence in Patients Treated with Clarithromycin and Omeprazole
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Background.Smoking may affect adversely the cure rate forHelicobacter pyloriinfection in patients treated with amoxicillin and omeprazole. Therapy with clarithromycin and omeprazole was tested for its effectiveness in the treatment ofH. pyloriinfection in smokers and nonsmokers.Materials and Methods.Patients with verified duodenal ulcer andH. pyloriinfection received clarithromycin 500 mg tid, in combination with omeprazole 40 mg/day, for 2 weeks, followed by omeprazole (20 or 40 mg daily) for 2 additional weeks according to a randomized, double‐blind, multicenter design. Patients were analyzed by their smoking status for the cure ofH. pyloriinfection, ulcer healing, and prevention of duodenal ulcer recurrence.Results.After treatment with clarithromycin and omeprazole,H. pyloriinfection was cured in 71% of the smokers and in 77% of the nonsmokers (evaluated 4–6 weeks after treatment). Overall ulcer healing was 95%, and overall ulcer recurrence was 19%. ForH. pylori–negative patients, ulcer recurrence was 12% in both smokers and nonsmokers. None of these values was significantly different when smokers were compared to nonsmokers.Conclusions.Therapy with clarithromycin and omeprazole is effective for cure ofH. pyloriinfection in smokers and nonsmokers. Smoking has no effect on duodenal ulcer healing or duodenal ulcer recurrence for patients treated with this regimen.
