Journal article
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Abstract
BACKGROUND & AIMS: The mechanisms underlying abdominal pain perception in irritable bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb nerve function leading to symptom perception. We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients.
METHODS: IBS patients were diagnosed according to Rome II …
Authors
Barbara G; Stanghellini V; De Giorgio R; Cremon C; Cottrell GS; Santini D; Pasquinelli G; Morselli-Labate AM; Grady EF; Bunnett NW
Journal
Gastroenterology, Vol. 126, No. 3, pp. 693–702
Publisher
Elsevier
Publication Date
March 2004
DOI
10.1053/j.gastro.2003.11.055
ISSN
0016-5085