Journal article
Interferon-Mediated Depression of Cytochrome P-450-Dependent Drug Biotransformation
Abstract
A general property of interferon-inducing agents is depression of cytochrome P-450-dependent drug biotransformation in liver. Evidence for a direct involvement of interferon is suggested by experiments carried out in inbred strains of mice carrying four distinct genetic loci which influence the levels of circulating interferon produced by specific viruses. For Newcastle disease virus (NDV), one autosomal locus (IF-1) determines a 10-fold …
Authors
SINGH G; RENTON KW
Journal
Molecular Pharmacology, Vol. 20, No. 3, pp. 681–684
Publisher
Elsevier
Publication Date
November 1981
DOI
10.1016/s0026-895x(25)14394-0
ISSN
0026-895X