Journal article
Ultrafast Separation and Analysis of Monoclonal Antibody Aggregates Using Membrane Chromatography
Abstract
We discuss a method for rapid and cost-effective analysis of monoclonal antibody (mAb) aggregates. Hydrophobic interaction membrane chromatography, which was previously shown to be highly suitable for such separation and analysis, was used in a recently developed format referred to as laterally fed membrane chromatography (or LFMC). A stack of rectangular polyvinylidene fluoride (or PVDF) membranes having 0.22 μm pores housed within a modified …
Authors
Madadkar P; Umatheva U; Hale G; Durocher Y; Ghosh R
Journal
Analytical Chemistry, Vol. 89, No. 8, pp. 4716–4720
Publisher
American Chemical Society (ACS)
Publication Date
April 18, 2017
DOI
10.1021/acs.analchem.7b00580
ISSN
0003-2700