Journal article
Sarco(endo)plasmic reticulum Ca2+ pump isoform SERCA3 is more resistant than SERCA2b to peroxide
Abstract
Sarco(endo)plasmic reticulum Ca2+ pumps are encoded by genes SERCA1, SERCA2, and SERCA3. Most tissues express SERCA2 Ca2+ pumps (splice SERCA2b) which are inactivated by reactive oxygen. In contrast, SERCA3 is expressed in tissues such as tracheal epithelium, mast cells, lymphoid cells, and aortic endothelium, which are frequently exposed to oxidative stress. Therefore, we compared SERCA3 and SERCA2b proteins for their sensitivity to oxidation. …
Authors
Grover AK; Samson SE; Misquitta CM
Journal
American Journal of Physiology, Vol. 273, No. 2, pp. c420–c425
Publisher
American Physiological Society
Publication Date
August 1, 1997
DOI
10.1152/ajpcell.1997.273.2.c420
ISSN
0002-9513