Journal article
Caloxins: a novel class of selective plasma membrane Ca2+ pump inhibitors obtained using biotechnology
Abstract
Plasma membrane Ca2+ pumps (PMCA) extrude cellular Ca2+ with a high affinity and hence play a major role in Ca2+ homeostasis and signaling. Caloxins (selective extracellular PMCA inhibitors) would aid in elucidating the physiology of PMCA. PMCA proteins have five extracellular domains (exdoms). Our hypotheses are: 1) peptides that bind selectively to each exdom can be invented by screening a random peptide library, and 2) a peptide can modulate …
Authors
Szewczyk MM; Pande J; Grover AK
Journal
Pflügers Archiv - European Journal of Physiology, Vol. 456, No. 2, pp. 255–266
Publisher
Springer Nature
Publication Date
May 2008
DOI
10.1007/s00424-007-0348-6
ISSN
0031-6768